Keynote Speakers

Richard Daneman received his Bachelor of Science McGill University, in Montreal Canada majoring in biochemistry.  He then received his Ph.D in developmental biology from Stanford University where he studied the molecular mechanisms that regulate blood-brain barrier formation in the laboratory of Dr. Ben Barres.  Dr. Daneman then started his own lab as a Sandler Fellow at UCSF, before moving to a position as Assistant Professor in the departments of Pharmacology and Neuroscience at the University of California, San Diego.  Dr. Daneman focuses his studies on understanding the molecular mechanisms that regulate blood-brain barrier (BBB) function during health and disease.  In his lab uses a combination of cellular, molecular and genetic approaches to understand the mechanisms of BBB formation and function, addressing important questions such as:  What are the mechanisms that regulate the formation and function of the BBB? How does the BBB interact with the neuronal circuitry to regulate brain function and behavior?  What are the molecular mechanisms that lead to BBB disruption during neurological disease? The overall goal of our work is to elucidate these mechanisms, such that we will be able to develop therapeutics to modulate the barrier to treat neurological diseases.  He has received a number of honors including the Klingenstein-Simons Award in Neuroscience, the Rita Allen Foundation Milton E. Cassel Scholar award, the AAA young investigator award, the ASPET Neuropharmacology Early Career award and the NINDS Landis Award for Outstanding Mentorship

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TBA

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Abstract
The choroid plexus forms an important brain barrier, produces CSF, and can also remove CSF from the ventricles. Because its epithelial cells express and secrete important factors that regulate brain function(s) throughout life, the choroid plexus has become an appealing target for CNS therapies. This presentation will describe (1) our latest work investigating the fundamental mechanisms of how the choroid plexus regulates the CSF, and (2) how we are harnessing this new information to design new treatments for neurologic diseases.

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Dr. Lehtinen received her Ph.D. in Neurobiology from Harvard University where she trained with Dr. Azad Bonni on molecular mechanisms regulating neuronal survival and death. She carried out early postdoctoral training with Anna-Elina Lehesjoki (University of Helsinki). In later training with Dr. Christopher A. Walsh (Harvard), they found that secreted factors in the CSF play active roles in instructing the development and health of the mammalian brain. Dr. Lehtinen established her own laboratory at Boston Children’s Hospital in 2012, where she takes an interdisciplinary approach to study the choroid plexus-CSF-system in the brain, with applications ranging from neural development to age-associated neurologic diseases.

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Biography

Academic positions, education, and research training
2018- Assistant Professor, Department of psychiatry and neuroscience, Faculty of medicine &
CERVO Brain Research Centre, Université Laval, Quebec City (Canada), http://menardneurolab.com/
2014-2018 Postdoctoral fellow, Icahn School of Medicine at Mount Sinai (Friedman Brain Institute, Fishberg Department of Neuroscience), New York (USA), advisor: Scott J. Russo, Ph.D.
2013-2014 Postdoctoral fellow, University of Montreal (Department of Medicine), University of Montreal Hospital Research Center (Canada), advisor: Pierrette Gaudreau, Ph.D.
2012-2013 NSERC R&D Scientist – New World Laboratories, Quebec Biotechnology Innovation Center (Canada)
2009-2012 CIHR postdoctoral fellow, McGill University (Department of Psychiatry), Douglas Mental Health University Institute, Montreal (Canada), advisor: Rémi Quirion, Ph.D., O.C., C.Q., MSRC
12/2008 Ph.D. Biophysics & Cell Biology, NSERC Alexander-Graham-Bell graduate scholar, Université du Québec Trois-Rivières, Department of Chemistry-Biology (UQTR, Canada), advisor: Guy Massicotte, Ph.D
09/2002 B.Sc. Biophysics, UQTR (Canada)

Awards and prizes (selected from a list of 24)
2021 Canadian College of Neuropsychopharmacology (CCNP) Young Investigator Award (2,000$ sponsored by Pfizer Canada Inc.)
2021 Nomination Associate Member – American College of Neuropsychopharmacology (ACNP)
2021 Brain & Behavior Research Foundation (BBRF, USA) 2020 Top 10 Leading Research Achievements
2020 Quebec Government Young Investigator Award, Finalist (2,000$)
2016 BBRF/NARSAD Young Investigator Award

Highlights of research funding over the past four years
2020-2026 Canadian Institutes for Health Research (CIHR) Project Grant (PI Menard)
2020-2025 CIHR Network Catalyst Grants The Canadian Brain Research Strategy (International Brain Initiative Canadian Secretariat) (Co-PI, PIs De Koninck & Illes)
2019-2025 Natural Sciences and Engineering Research Council of Canada Discovery Grant (PI Menard)
2020-2024 Canada First Research Excellence Fund (CFREF) Sentinel North Major Call for Proposals 2020-2023 (two grants, one as PI and one as co-I)
2019-2024 Canadian Foundation for Innovation (CFI) John R. Evans Leaders Fund (PI Menard)
2018-2024 CFREF Sentinel North Research Chair on the Neurobiology of Stress and Resilience (PI Menard)
2020-2022 Brain Canada 2019 Azrieli Future Leader in Canadian Brain Research (PI Menard)
2019-2022 CIHR/NSERC/SSHRC – New Frontiers in Research Fund – Exploration (Co-PI, PI Alain Doyen)

Most significant scientific contributions (h-index: 31, i10-index: 46, 4829 citations)
I did publish 55 peer reviewed journal articles including in Nature, Nature Neuroscience, Nature Medicine, Neuron, Nature Communications, PNAS, Molecular Psychiatry, Biological Psychiatry and Neuropsychopharmacology. In the last 4 years I gave over 60 invited seminars and talks in symposiums at international, national, and local events. I am also regularly invited for knowledge transfer activities including in the medias. http://www.ncbi.nlm.nih.gov/sites/myncbi/1ZGut7L5PQcAh/bibliography/47662464/public/?sort=date&direction=descending
Supervision and training of students and postdocs: Since opening my lab in 2018, I did train 1 postdoc, 5 PhD, 5 MSc and 18 undergraduate students. Almost all secured highly competitive and prestigious funding with my support.

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Robert Thorne is currently a full-time Denali Fellow with Denali Therapeutics (Sept 2018-) and an Adjunct Associate Professor in the Department of Pharmaceutics at the University of Minnesota (Feb 2019-), following earlier service on the faculty at New York University School of Medicine (2008-2010) and the University of Wisconsin-Madison (2010-2018). His research has focused on the physiology of brain fluids, perivascular pathways for CNS biodistribution, and novel methods/routes/strategies for drug delivery to the brain and spinal cord. Dr. Thorne is the Vice President of the International Brain Barriers Society (https://www.ibbsoc.org/) and has played a major organizational role for many key meetings in the CNS barriers field, including serving as the elected Chair of the 2016 ‘Barriers of the CNS’ Gordon Research Conference.  

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Blood-brain barrier (BBB) dysfunction contributes to synaptic, neuronal and cognitive dysfunction in animal models and humans. I will review 1) findings in transgenic models where the genetic mutations or defects are found within brain endothelial cells leading to synaptic deficits and neurodegenerative process; 2) neuroimaging and fluid biomarker studies in humans suggesting that BBB breakdown leads to early cognitive dysfunction within the Alzheimer’s and non-Alzheimer’s disease trajectories including the effects of APOE4, the main susceptibility Alzheimer’s gene; and 3) pharmacological and genetic strategies and gene therapy targeting the BBB signaling mechanisms to control neurodegenerative process and/or slow down cognitive decline.

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Zlokovic is University Professor, Director of the Zilkha Neurogenetic Institute, and professor and chair of the Department of Physiology and Neuroscience at the University of Southern California. He studies the role of cerebral blood vessels in Alzheimer’s disease and stroke. He identified the cellular and molecular mechanisms causing blood-brain barrier (BBB) breakdown, and showed that BBB breakdown can initiate neuronal and synaptic dysfunction, and is an early biomarker of human cognitive dysfunction. Thomson Reuters/Clarivate Analytics listed Zlokovic in top one percent of the most-cited authors in the field of neurosciences and behavioral sciences for 20 consecutive years.

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